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Nutr Cancer 66 , 757773 (2014)

CONCERN #2: SYSTEMIC INFLAMMATION THAT FUELS CHRONIC DISEASE Description: This isn't the acute swelling from a sprain

HGF is the sole ligand for c-Met, and HGF binding with c-Met can lead to c-Met phosphorylation, which activates several intracellular signaling pathways, including MAPK, STAT3, and PI3K/AKT