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doi: 10.1016/j.freeradbiomed.2016.12.009 51 uczajWGgotekASkrzydlewskaE

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At the joint inflammatory site, abnormal modulation of mTOR signaling results in continuous feedback between stromal cells and infiltrating immune cells, leading to persistent inflammation and tissue damage, driving the pathological tissue refactoring and eventually causing organ dysfunction [4]

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