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Impaired oral hygiene and genetic alterations resulting in susceptibility to malignancies such as Fanconi anemia have also been implicated as risk factors

Besides, due to complex multidrug regimens of CHD patients, this study cannot fully analyze drug-specific effects on gut microbiota, metabolites, or immune parameters

In the intestine for example, several drug metabolising enzymes are presumed to decrease the bioavailability of orally administered drugs or to activate environmental carcinogens

Archived from the original on 12 August 2020

Scientists dont exactly know why this reaction happens but suspect that one reason is that the killed spirochetes break down and release toxins, and our immune systems response to this spill is what causes the symptoms of the Jarisch Herxheimer reaction