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Diese Frage bleibt jedoch offen und erfordert spezifische Untersuchungen

Redis et al., 2016)

Consistency matters far more than precision

Most patients achieve stable INR within 4-8 weeks of starting warfarin, assuming consistent dosing, diet, and no medication changes

The level of strain heterogeneity was estimated by calculating the number of nonsynonymous substitutions detected out of all positions mapped with a depth of coverage of at least 10 reads and base quality of at least 30 (a minimum of 100 positions were needed to estimate strain heterogeneity)