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In mouse studies, SLU-PP-332 has been characterized as an exercise mimetic compound: Increasing expression of PGC-1linked mitochondrial gene programs Raising resting energy expenditure and fat oxidation Reducing adiposity and improving glucose tolerance in diet-induced obese mice Boosting treadmill running capacity and endurance-type performance without requiring extra training Press coverage and preclinical papers describe SLU-PP-332 as making the body act like it is training for a marathon, even in sedentary animals, by shifting muscle toward more oxidative fiber types and denser mitochondria

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These effects are linked to increased beta-3 adrenergic receptor (ADRB3) activity (2), which promotes fat burning in adipose tissue and thermogenesis in skeletal muscle (3)

Beta-3 receptors are highly expressed in adipose tissue but have limited expression in most other tissues in adult humans