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A mutation-independent CRISPR-Cas9-mediated gene targeting approach to treat a murine model of ornithine transcarbamylase deficiency

The intervention diet represented a single experimental treatment for dogs in both the NT and T diet groups (i.e., changing the diet from what the dogs had been originally eating at the time of diagnosis to an intervention diet that had the properties noted above)

Strategies may also include establishing a set time to sleep and a regular wake-up time, creating a quiet sleep environment with a comfortable room temperature, avoiding factors that interfere with sleep, using relaxation exercises, getting out of bed and engaging in another activity, such as reading, if unable to sleep

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Early Childhood & Proper Nurturing