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The clinically normal heterozygous carriers for this disease have about half of the normal glutathione synthetase activity, as predicted, but have normal clinical phenotypes, cellular glutathione levels, and 5-oxoproline excretion (53)

doi: 10.1186/s40170-021-00258-5

10.3390/medicina43080076 16

regulation of NCF1/NADPH oxidase by such PAHs may be involved in atherosclerotic heart disease associated with vascular disease such as sclerosis (81)