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Interestingly, the deletion of Slc7a11 (which encodes xCT) in animals results in viable offspring 26 , suggesting that tissues (and potentially tumors) can obtain cysteine from another source

Together, these results mean that the metabolites of gut microbiota disturb regulation of joint FTN and homeostasis of iron, thereby may inducing iron overload that triggers ferroptosis and accelerate the development of OA