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This, like the neuropathy, has been attributed to a failure of the synthesis of SAM, which is needed in methylation of biogenic amines (e.g., dopamine) as well as that of proteins, phospholipids, and neurotransmitters in the brain (Fig

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The equilibrium between mitochondrial dynamics and mitophagy is essential for the continuous renewal of mitochondria and the generation of new mitochondria (Palikaras and Tavernarakis, 2014)