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doi: 10.3168/jds.S0022-0302(02)74415-9 [DOI] [PubMed] [Google Scholar] 51

By modulating cell fate, ROS play a broad and integral role in the pathogenesis of various diseases

He ZJ, Zhu FY, Li SS, Zhong L, Tan HY, et al

Cellular glutathione peroxidase deficiency and endothelial dysfunction

When lipid accumulation exceeds the protective mechanisms, hepatocytes become injured, process known as lipotoxicity, and release a number of inflammatory mediators that lead to recruitment and activation of ECM-forming cells with excessive deposition of a distorted ECM, leading to liver fibrosis