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As a serine/threonine kinase, GSK3 has a strong preference for substrates harboring a S/TXXXS/T motif (X, any amino acid), which is usually primed as a target for GSK3 by phosphorylation of a residue four or five amino acids to the C-terminal side of the motif 12

Ganta CK, Lu N, Helwig BG et al (2005) Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system

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