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Recent studies indicate that the absence of MT1 receptors in mice leads to increased nocturnal IOP and a decrease in RGCs, highlighting a possible connection between impaired melatonin signaling and the development of glaucoma (68)

WS patient samples and WS animal models' NAD+-deficient cells showed impaired mitophagy (selective degradation of defective mitochondria) (25)

As the lack of dose-responsive effect of vitamin B12 on NAFLD in this study, it is hard to apply the results of the present study to clinical practice without recommendation of a beneficial range