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The authors proposed that alkylamides were the main class of compounds responsible for the this strong bioactivity of extracts

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Several additional loci showed directionally consistent effects but did not reach statistical significance in external datasets

Unexplained fatigue that does not respond to foundational interventions, vague or migrating joint pain without clear orthopedic or infectious disease explanation, persistent low-grade inflammatory markers without obvious infection, skin changes including rashes, photosensitivity, or Raynauds phenomenon, and early or unexplained thyroid antibody elevation all warrant closer investigation