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doi: 10.3390/ani9080573 78

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For simplicity, we assume that the activations of GCL and GPX are equal, though that may not be the case

First, in non-malignant tissues, PDK isoforms play essential physiological roles, particularly in highly energy-demanding organs such as the heart and skeletal muscle, where they regulate substrate utilization by limiting carbohydrate oxidation and promoting metabolic flexibility [190, 191]

Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells