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Following pathogen recognition, NO accumulation occurs concomitant with an oxidative burst, which consists of a biphasic production of apoplastic ROS at the site of attempted invasion (Romero-Puertas et al., 2004)

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Soluble IL-18 receptor beta (sIL-18R) modulates Treg cells and Th17 cells similarly to IL-18BP, which suppresses collagen-induced arthritis (Veenbergen et al., 2010)