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APR-246, also known as PRIMA-1MET, is a promising new therapeutic agent that targets TP53 mutated cancers

It provides a reliable way to stimulate ovulation and testosterone production

doi: 10.1007/s00253-021-11114-3 85 DemonchyJ.BiardL.Clere-JehlR.WalletF.MokartD.MoreauA

29 Progressively several other nanomedicines were reported as potential candidates for RA therapy like MTX combined with nanoemulsions, 30 siRNA-loaded chitosan nanoparticles, 31 curcumin-loaded carboxy methyl cellulose acetate (CMCAB), 32 exosomes as biomimetic particles, 33 stimuli-responsive liposomes, 34 MTX and siRNA loaded carbon nanotubes, 35 poly(amidoamine) (PAMAM) dendrimers functionalized with chondroitin sulphate and with anti-TNF- to provide anti-inflammatory properties 36 and mesoporous silica nanoparticles encapsulating dexamethasone 37 to deliver the traditional drugs