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10.1038/nrc3430 99 WangS

Bloom, J

& Ishikawa, H

GBA1 mutations are associated with sex-specific serum metabolomic profiles in Parkinsons disease patients compared to healthy controls GBA1 mutations reduce the lysosomal activity of -glucocerebrosidase, disrupting sphingolipid metabolism, protein quality control, ERGolgi trafficking, and the clearance of -synuclein (Blauwendraat et al., 2020

Brain Res 815:8188 Liddell JR, Dringen R, Crack PJ, Robinson SR (2006a) Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes