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10.1016/j.molimm.2021.01.009 190 WangL.WangJ.RenG.SunS.NishikawaK.YuJ.et al (2023a)

In some tissues, such as, e.g., the kidneys or the liver, the remethylation reaction can also be carried out by other enzymes such as betaine-homocysteine-S-methyltransferase (BHMT) [17]

The results showed that the most significant anti-fibrotic outcome was obtained with the combination of PEG2-siRNAs-NLCs [134], which was a successful application of the combined use of the delivery of NPs and gene therapy