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The HO-1/NQO-1 pathway inhibits COX-2 expression, thereby suppressing the expression and secretion of the inflammatory factors interleukin-1 (IL-1), IL-6, interleukin-8 (IL-8), interleukin-25 (IL-25), and interleukin-33 (IL-33)

doi: 10.1002/ana.24369, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Sevigny J., Chiao P., Bussire T., Weinreb P

Additionally, M2-associated iron recycling pathways (HMOX1 upregulation, heme metabolism) can be targeted to shift intracellular iron pools toward pro-ferroptotic states

This observation indicates that Fgr may play a role in development of radiation-induced fibrosis [60]

These cells - mainly blood and gut cells - are all replaced with new ones, but the way our bodies rid themselves of material could have profound implications for cancer therapies in a new approach developed by Stanford Medicine researchers