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Chemotherapy-induced peripheral neuropathy: A current review

2025 Dec;17(12):3377-3406

In MCF-7 breast cancer cells, the development of resistance to DOX was linked to the redistribution of the drug to the perinuclear region, its colocalization with lysosomes and autophagosomes, and elevated levels of autophagy markers such as LC3-II and p62 (120)

Significantly, an important mechanism for this resistance is the role of LPA in increasing Nrf2 stability and activation of the ARE

In recent years, it has also become a popular wellness treatment, helping people to recover from fatigue, nutrient imbalance, illness, stress, and even hangovers