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Figure 2 synthesizes these considerations into a constraint-aware development framework that integrates data-driven design prioritisation, TME-informed patient stratification, rational platform simplification and regimen-level coordination

Pen Dosage Chart GLP-2T 5-Amino-1MQ Slu-pp-332 Capsules Dosage & Protocols Variations GLP-2T Standard Research Protocol Dose: 2.5 5 mg (variant 5 mg pen = 76152 clicks / variant 10 mg pen = 2550 clicks / variant 15 mg pen = 2550 clicks) Duration: 8 12 weeks Frequency: 1 weekly Cycle Interval: Optional 2-week pause Goal / Description: For basic metabolic modulation studies Therapeutic Research Protocol Dose: 10 15 mg (variant 15 mg pen = 100150 clicks) Duration: 24 48 weeks Frequency: 1 weekly Cycle Interval: Repeat after 1 month Goal / Description: Modeled on SURPASS/SURMOUNT designs

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