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& Lentz, J

However, complete or near-complete recovery of biochemical and neurophysiological properties is possible after vitrification and rewarming of brain slices and brain organoids [[1416, 26, 33]], for which the BBB is not limiting, which implies that brain cell permeability to cryoprotectants is not a major problem

doi: 10.3389/fpsyt.2021.703452 173

Collectively, these mechanisms encompassing PI3K/Akt activation, modulation of Sirt1-Foxo1, reduction of oxidative stress, inhibition of apoptosis, and cholinergic receptor-mediated anti-inflammatory effects, provide a robust biological basis for curcumins neuroprotective and cytoprotective effects in PD (Nebrisi, 2021)