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These findings may also explain why patients with nonsense mutations, and therefore more severe loss of enzyme function had the highest level of the complement anaphylatoxins, C3a and C5a (33)

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The most representative example of such adducts is represented by the reaction of hydroxyl radicals with the DNA base Guanine, resulting in the formation of the 8-OH Guanine adduct (see Fig

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Keap1 knockdown has been shown to improve lung cell proliferation after birth in neonatal mouse models, accompanied by an increase in the expression level of the antioxidant gene (nuclear GSH)