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Kuniyasu et al., 1992

For instance, increase of Akkermansia, Catabacter, Lactobacillus, Bifidobacterium, Bifidobacteriaceae, Ruminococcaceae, Verrucomicrobiaceae , and reduction in Roseburia, Faecalibacterium, Prevotellaceae, Blautia, Coprococcus , and Lachnospira have been noted in individuals with PD (159, 169)

Pb has been shown to decrease mGluR5 mRNA and protein expression in a dose-dependent manner, impairing LTD and attenuating mechanisms of synaptic plasticity critical for learning and memory [87]

Therefore, induction of WAT apoptosis may also contribute to the effects of leptin on the reduction of fat depots, mainly acting at the central level, although mechanisms involved need to be further explored