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An excessive shift in the balance would generate reductive stress leading to the protein aggregates and proteotoxicity as was reported in myocardium (Rajasekaran et al

Taken together, these data suggest that the primary function of FTMT may be regulatory and protective, rather than a constant buffer of mitochondrial iron pools 42,43

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doi: 10.3389/fendo.2021.645194 142 HashemiPPezeshkiS

Developing agents targeting context-specific chain configurations, particularly PROTACs exploiting newly identified E3 ligase interfaces, could transform ubiquitin adaptability from a resistance mechanism into an actionable therapeutic vulnerability