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It is crucial to note, however, that recent studies highlight significant systemic side effects of MCT4 inhibition due to its broad tissue expression, which may limit its clinical translational potential and necessitate the development of tissue-specific delivery strategies [138]

Similarly, a study using RNA-seq in the glutathione auxotrophic Streptococcus pyogenes (HKU16 gshT strain) revealed an extensive transcriptional perturbation under glutathione-decreasing conditions (11), showing expression changes in 165 genes, the majority of these genes (75%) downregulated, including several virulence-determinant genes

This protect effect of 5-HT on APAP hepatotoxicity was at least partially attributable to a significantly decreased inflammation, oxidative stress, GSH depletion, peroxynitrite formation, hepatocyte apoptosis and ER stress, elevated hepatocyte proliferation, activation of 5-HT2B receptor and less activated JNK and HIF-1

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