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The "rapid reversal" group (approximately 10-15% of users) experiences concerning quick benefit loss within weeks of discontinuation, typically involving users who applied very high concentrations creating dependency-like patterns, possessed severe underlying skin conditions requiring ongoing treatment, experienced significant lifestyle or environmental stressors overwhelming skin resilience, discontinued abruptly without tapering from high-dose protocols, or had unrealistic perception inflation during treatment leading to exaggerated reversal perception

386,387,388,389 In the huge and complex neural network involving social behaviour, the PFC and its massive reciprocal loop connections constitute a top-down social behaviour regulation system

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Unno K, Tanida N, Ishii N, et al

J Ethnopharmacol 264:113224