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Because bup/nx has very high opioid receptor affinity, it can precipitate withdrawal in patients who are opioid-intoxicated or in very early withdrawal

Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants

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