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Lysophosphatidic acid receptor 5 contributes to imiquimod-induced psoriasis-like lesions through NLRP3 inflammasome activation in macrophages

Lipinska et al., 2025), EVs have been applied using heterogeneous experimental protocols, with doses generally ranging from low g/mL concentrations (310 g/mL) to higher fixed doses around 120200 g/mL, and exposure times spanning from short co-culture periods of a few hours (up to 14 h) to prolonged treatments covering complete in vitro maturation windows according to the specie (approximately 1838 h)

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Depending on the activation state (resting or activated), noradrenaline can affect their functions through different ARs, achieving similar results (88)

The study population characteristics were: median age of 64 years (range: 34 to 84), 49% age 65 years or older, 59% male, 94% White and 3% Asian, and 18% with history of brain metastases at baseline