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KU-57788, a selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), has shown promise in cancer therapy when combined with radiotherapy and chemotherapy

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Similarly, the proprietary probiotic mixture (Prohep) improved hepatic lipid metabolism by downregulating key cholesterol metabolism genes and fatty acid metabolism genes, reducing the secretion of pro-inflammatory cytokines (IL-17, TNF- and IL-6), and increasing the secretion of the anti-inflammatory cytokine IL-10, as well as led to a significant shift in the gut microbiota structure and increased the levels of SCFAs, specifically acetate and isobutyrate, which are beneficial for gut health in HFD diet-induced MASLD mice model [93]