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Additional information Peer review information Nature Chemistry thanks Junjie Yao, Deju Ye and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Compounded low-dose naltrexone is necessary to achieve the micro-dose strengths not available in standard commercial products

Genetic variation within and between strains of outbred Swiss mice

Then polydopamine- coated PLGA/CNT scaffolds were washed with DI water three times to remove the unbound dopamine

While these compounds show promise in preclinical studies, their safety and efficacy in humans remain to be established through proper clinical trials