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Oral supplements have also been shown to be effective at treating vitamin B12 deficiency

The foundation of effective weight management consists of lifestyle modifications , including: A reduced-calorie, nutritionally balanced diet tailored to individual needs and preferences Regular physical activity, with UK Chief Medical Officers and NHS recommending at least 150 minutes of moderate-intensity aerobic activity per week Behavioural interventions addressing eating patterns, triggers, and psychological factors Long-term support and follow-up to maintain weight loss Pharmacological interventions are considered as adjuncts to lifestyle changes, not replacements

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Stomach acid and pepsin are required to free food-bound B12, which then binds to salivary R-proteins