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Fu X, Feng Y, Shao B, Zhang Y (2019) Activation of the ERK/Creb/Bcl2 pathway protects periodontal ligament stem cells against hydrogen peroxide-induced oxidative stress

10.1073/pnas.1102281108 27 de SousaV

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This disrupts various signaling pathways, including those involved in tau phosphorylation, function of synapses, and survival of neuron cells

This is invasive and not always accessible, leading to severe diagnostic delays estimated to be between 4 to 11 years and a massive underestimation of disease prevalence