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Oxidative stress, reductive stress and antioxidants in vascular pathogenesis and aging

To critically appraise mechanisms and levels of evidence ( in vitro, in vivo , clinical) for vitamin E and C, glutathione and its precursors, polyphenols (quercetin, resveratrol, curcumin), Crocus sativus carotenoids (crocin/safranal), and indirect modulators (e.g., omega-3, folinic acid), emphasizing study quality, translational relevance, and limitations

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A phase II open-label study was conducted amongst 10 FRDA patients to evaluate the safety and efficacy of (+)-epicatechin