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Severe intrahepatic cholestasis of pregnancy is a risk factor for preeclampsia in singleton and twin pregnancies

Differentially expressed genes are significantly enriched in redox processes (GO:0055114) and oxidoreductase activity (GO:0051903, GO:0004022, GO:0050607), highly consistent with the aforementioned biochemical phenotypes

Quiles MT, Arbs MA, Fraga A, de Torres IM, Revents J, Morote J

FOXO4-DRI is also known as Proxofim (research designation), FOXO4 D-Retro-Inverso peptide (full descriptive name), Forkhead box O4 (DRI) (gene-derived name), and FOX04-DRI (alternative spelling)

Endothelial dysfunction has been demonstrated in vivo (306, 311), in the large vessels of ME/CFS patients (307, 311) through flow-mediated dilation (FMD) and in the microcirculation through post-occlusive reactive hyperaemia