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Liu Y, Guo X, Hu X, et al

SELENOP maintains the activity of glutathione peroxidase 4 (Gpx4) by binding to LRP-1, preventing lipid peroxidation and ferroptosis, both of which contribute to neurodegeneration in AD [15]

doi: 10.1016/j.fertnstert.2022.09.014

However, this ROS decrease did not impact the drug-related apoptosis rate

Therefore, local glutamate/glutamine dysregulation could be used as a biomarker of HIV infection, be exploited in potential treatments, and could also explain the increased susceptibility of infected individuals to several types of cancer that may also use glutamine/glutamate as a major source of energy to survive 22,94