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or saline 5.0 mL/kg i.p.) given at 5 min after isoprenaline, we assessed the early occlusion-like syndrome in the isoprenaline-treated rats as an early multi- Biomedicines 2022,10, 265 4 of 38 organ failure (brain, heart, lung, liver, kidney and gastrointestinal lesions), thrombosis, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension, full presentation

doi: 10.7554/eLife.45100 47 TsiotiI.SteinerB

Why Combining These Therapies Works Better Individually, each therapy is effective