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Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer

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Once inside the cell, the -glutamyl amino acid can be further metabolized to release the amino acid and 5-oxoproline, which can be converted to glutamate and used for GSH synthesis

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overexpression of UBB+1 results aggregation of ubiquitinated protein in UBB+1 overexpressing cells (van Tijn et al., 2007) and mice (Irmler et al., 2012)