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[5] When there is an abundance of ROS and not enough antioxidants to help neutralize the free radicals, it can cause significant damage to macromolecules such as lipids, proteins, and DNA

10.1016/j.resmic.2015.09.006 [DOI] [PubMed] [Google Scholar] Agusti A., Molina-Mendoza Gv., Tamayo M., Rossini V., Cenit Mc., Frances-Cuesta C., et al