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These include areas of potential bias such as whether studies used blinding and control groups, and if the study methodology was explicit

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However, clinical outcomes have been mixed: a phase II randomized controlled trial (RCT) in early-onset PD patients showed that short-term DFP treatment was safe but only trended toward motor improvement (Martin-Bastida et al., 2017)

Hribal ML, Nakae J, Kitamura T, Shutter JR, Accili D: Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors

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