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During the third week of embryonic development, gastrulation establishes the three primary germ layers

Luo JL, Hammarqvist F, Andersson K, Wernerman J

What Causes Freckles on The Face They can happen due to a mix of sun exposure, genetics, and skin type: Sun Exposure: UV rays trigger your skin to produce more melanin

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Fish Physiol Biochem 9:369376 Van Veld PA, Vogelbein WK, Cochran MK, Goksoyr A, Stegeman JJ (1997) Route-specific cellular expression of cytochrome P4501A (CYP1A) in fish ( Funduls heteroclitus ) following exposure to aqueous and dietary benzo[a]pyrene