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The relative stability may relate to the disulfide bond in the C-terminal cyclic region

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Haddad JJ, Land SC: Nuclear factor-B blockade attenuates but does not abrogate lipopolysaccharide-dependent tumor necrosis factor- biosynthesis in alveolar epithelial cells

While both traditional clinical biomarkers of kidney function [e.g., serum creatinine (SCr), blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), and creatinine clearance (CrCl)] and newer subclinical biomarkers of kidney injury [e.g., urinary kidney injury molecule 1 (KIM-1), beta-2 microglobulin (B2M), neutrophil gelatinase-associated lipocalin (NGAL), calbindin, etc.] can be used to detect cisplatin-induced AKI, published PKTD models are limited to using only traditional clinical biomarkers