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Although ML210 (Figure 1A) lacks an obvious protein-reactive group through which it could act as a GPX4 inhibitor, data from the Cancer Therapeutics Response Portal (CTRP at 79 reveal that it exhibits a pattern of cell killing across 821 cancer cell lines that is strikingly similar to that of chloroacetamide GPX4 inhibitors (1 S ,3 R )-RSL3 (RSL3) and ML162 (Figures 1A and 1B)

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15 Lipid peroxidation Level of lipid peroxidation was measured in different experimental groups