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Description

In parallel, the dysregulation of clock genes compromises the temporal expression of metabolic genes, completing the chain of events leading to a collapse in the temporal organization of physiological processes and triggering a progressive dysfunctional metabolic state

The strong association of PSC with IBD has drawn much attention to the potential role of the inflamed colon

doi: 10.1161/HCQ.0000000000000120 37

Early phase (weeks 1-4) The first noticeable changes typically involve sleep quality

Data availability The datasets generated and analyzed during the current study have been made available as Supplementary Dataset S1 (metabolite levels and cognitive data)