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It participates in over 500 enzymatic reactions and is essential for energy production, DNA repair, and cellular signaling

10.1016/s1535-6108(04)00059-5 [DOI] [PubMed] [Google Scholar] Kanayama G., Hudson J

Control Groups: Vehicle control NAD+ precursor supplementation (NR, NMN) for comparison NNMT overexpression models (opposite phenotype) Mechanism Investigation: Key research questions: Are effects mediated primarily through NAD+ elevation

This suggests that it might be more beneficial to check red blood cell folate instead of serum folate in people with Down syndrome

10.1038/s12276-019-0216-4 45 HeW.CikM.Van PuyveldeL.Van DunJ.AppendinoG.LesageA.et al (2002)