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The sedimented liquid layer containing tumescent fluid and blood components was discarded

In postmortem central nervous system tissues from ALS patients, particularly in lower motor neurons, reduced levels of 5mC and 5hmC have been observed, correlating with the presence of TDP-43 proteinopathies (150)

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In immunological contexts, damage-associated molecular patterns (DAMPs) release pro-inflammatory mediators such as HMGB1 (high mobility group box 1)