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Unlike steroids which often override the bodys natural systems peptides typically stimulate or support existing pathways , making them safer and more physiological in many cases

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Imbalances between glutamate and GABA, which are strongly implicated in neuropsychiatric disorders like MDD [77], can lead to excitotoxicity, whereby excessive glutamate activation of NMDARs and AMPARs triggers calcium overload, oxidative stress, and cell death [78]

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However, the effect of the genotype was observed with HPC, which tended to increase TLR4 expression relative to the TSL genotype