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Description

The orally active PK activator mitapivat is the first approved therapeutic agent that is clinically beneficial for effective treatment of patients with PK deficiency (15, 16)

Following hematoxylin and eosin (HE) staining and Masson staining (Beyotime, Shanghai, China), slices were sealed and observed under a microscope

10.1111/j.1471-4159.2011.07536.x 249 WinglerK.HermansJ

Priorities for research include head-to-head evaluation of analogs in EMS models with integrated pharmacokineticpharmacodynamic mapping and iterative chemistry to lower promiscuous binding without compromising on-lesion potency