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Additionally, the methylation status of several DMPs in the SCEZ (such as SHANK3, SBF1, and MCF2L) was validated through methylation-specific qPCR (232)

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4a), we further found that YBX1 mRNA levels also decreased in shGDH1 cells and were rescued by -KG (Fig

However, endothelial dysfunction or endothelial cell death can cause vascular barrier disruption, vasoconstriction and diastolic dysfunction, vascular smooth muscle cell proliferation and migration, inflammatory responses, and thrombosis, which are closely associated with the progression of several diseases, such as atherosclerosis, hypertension, coronary atherosclerotic heart disease, ischemic stroke, acute lung injury, acute kidney injury, diabetic retinopathy, and Alzheimers disease