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In other cases, leukonychia may result from rare disorders, including: Bart-Pumphrey syndrome, which can cause nail abnormalities, knuckle issues, and hearing loss Bauer syndrome, which may cause leukonychia and skin cysts Buschkell-Gorlin syndrome, which can cause nail problems, kidney stones, and skin cysts Darier disease (keratosis follicularis), which can cause nail abnormalities and wart-like blemishes Frequent manicures Frequent manicures may also cause damage that results in these white spots on your nails

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